Search Result

Results for "

local anesthetic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Aldehyde Dehydrogenase (ALDH) (1) Apoptosis (1) Bacterial (2) Calcium Channel (4) Endogenous Metabolite (1) ERK (1) Fungal (1) Glucosidase (1) iGluR (2) Isotope-Labeled Compounds (1) mAChR (2) MEK (1) Monoamine Transporter (1) nAChR (1) NF-κB (1) Parasite (1) Phosphodiesterase (PDE) (2) Potassium Channel (2) Sodium Channel (7) TRP Channel (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Infection (3) Metabolic Disease (1) Neurological Disease (11)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W005637

Orthocaine

Others Neurological Disease

Orthocaine is a local anesthetic agent (extracted from patent WO2002089849A1) .

Orthocaine	Others	Neurological Disease
Orthocaine is a local anesthetic agent (extracted from patent WO2002089849A1) .

HY-B0517

Mepivacaine	Sodium Channel	Neurological Disease
Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization .

HY-B1704

Nisoxetine 1 Publications Verification	Monoamine Transporter Sodium Channel	Neurological Disease
Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a K_d of 0.76 nM. Nisoxetine is an antidepressant and local anesthetic, it can block voltage-gated sodium channels .

HY-105613

Metabutoxycaine

Others Others

Metabutoxycaine is a local anesthetic .
HY-W694291

Clibucaine

Others Others

Clibucaine is a piperidine derivative possessing local anesthetic properties. Clibucaine can be used as a local anesthetic agent .
HY-105525A

Sameridine hydrochloride

NIH 10908
Others Others

Sameridine hydrochloride is a local anesthetic and local analgesic .
HY-B2080A

Etidocaine hydrochloride

EDC hydrochloride
Others Infection Others

Etidocaine (hydrochloride) is a long aminoamide local anesthetic .
HY-B2080

Etidocaine

EDC

Etidocaine (EDC) is a long aminoamide local anesthetic .
HY-B1755

Risocaine

Propyl 4-aminobenzoate

Risocaine (propyl 4-aminobenzoate) is a local anesthetic .
HY-16259

Indecainide hydrochloride

LY 135837
Others Cardiovascular Disease

Indecainide hydrochloride is a potent and orally active class I local anesthetic antiarrhythmic agent .
HY-B1288A

Oxybuprocaine

Benoxinate; Novesinol; Oxybucaine

Oxybuprocaine is a short-acting ester-type local anesthetic agent used in ophthalmology and otolaryngology .

Metabutoxycaine	Others	Others
Metabutoxycaine is a local anesthetic .

Clibucaine	Others	Others
Clibucaine is a piperidine derivative possessing local anesthetic properties. Clibucaine can be used as a local anesthetic agent .

Sameridine hydrochloride NIH 10908	Others	Others
Sameridine hydrochloride is a local anesthetic and local analgesic .

Etidocaine hydrochloride EDC hydrochloride	Others	Infection Others
Etidocaine (hydrochloride) is a long aminoamide local *anesthetic* .

Etidocaine EDC
Etidocaine (EDC) is a long aminoamide local *anesthetic* .

Risocaine Propyl 4-aminobenzoate
Risocaine (propyl 4-aminobenzoate) is a local anesthetic .

Indecainide hydrochloride LY 135837	Others	Cardiovascular Disease
Indecainide hydrochloride is a potent and orally active class I local anesthetic antiarrhythmic agent .

Oxybuprocaine Benoxinate; Novesinol; Oxybucaine
Oxybuprocaine is a short-acting ester-type local anesthetic agent used in ophthalmology and otolaryngology .

HY-107915

Levonordefrin (-)-Cobefrin; (-)-α-Methylnoradrenaline; (-)-Nordefrin	Adrenergic Receptor	Others
Levonordefrin, a common alternative to levoepinephrine as a vasoconstrictor in dental local anesthetic preparations, is usually used in fivefold higher concentrations. Levonordefrin is generally considered equivalent to epinephrine .

HY-105651A

Butalamine hydrochloride	Others	Cardiovascular Disease
Butalamine (hydrochloride) is a peripheral vasodilator with local anesthetic effects. :Butalamine (hydrochloride) can produce in animals coronary vasodilation, local anaesthesia, analgesia and a papaverine like action in duodenal preparations. Butalamine (hydrochloride) causes a slowing in rate of spontaneous activity, a decrease in amplitude and a reduction in isolated human smooth muscle .

HY-B1704A

Nisoxetine hydrochloride 1 Publications Verification
Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenaline transporter (NET), with a K_d of 0.76 nM. Nisoxetine hydrochloride is an antidepressant and local anesthetic, it can block voltage-gated sodium channels .

HY-B1726

Phenacaine Holocaine
Phenacaine (Holocaine) is a local anesthetic. Phenacaine inhibits the specific calmodulin-dependent stimulation of erythrocyte Ca ²⁺-ATPase and cyclic nucleotide phosphodiesterases from brain and heart .

HY-B1551

Benzonatate Benzononatine
Benzonatate (Benzononatine) is a peripheral oral antitussive that dampens the activity of cough stretch receptors. Benzonatate has sodium channel-blocking properties and local anesthetic effects on the respiratory stretch receptors due to a tetracaine-like metabolite .

HY-B0517S

Mepivacaine-d3	Sodium Channel	Neurological Disease
Mepivacaine-d₃ is the deuterium labeled Mepivacaine. Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization[1][2].

HY-B0549A

Flavoxate hydrochloride Rec-7-0040; DW61	Phosphodiesterase (PDE) Calcium Channel mAChR	Neurological Disease
Flavoxate hydrochloride is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate hydrochloride is an antispasmodic agent and muscarinic mAChR antagonist. Flavoxate hydrochloride shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate hydrochloride can be used for the research of overactive bladder (OAB) and lower urinary tract infections .

HY-W357818

Glycinexylidide GX	Sodium Channel ERK MEK NF-κB	Cancer
Glycinexylidide (GX) is the active metabolite of Lidocaine. Lidocaine is a local anesthetic that inhibits sodium channels involving complex voltage and dependence. Lidocaine also reduces the growth, migration and invasion of gastric cancer cells. Glycinexylidide has research potential for use in anesthesia, cancer, and cardiovascular disease .

HY-B0549

Flavoxate Rec-7-0040 free base; DW61 free base	Phosphodiesterase (PDE) Calcium Channel mAChR	Neurological Disease
Flavoxate is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate is an antispasmodic agent and muscarinic mAChR antagonist. Flavoxate shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate can be used for the research of overactive bladder (OAB) and lower urinary tract infections .

HY-B0379A

Adiphenine hydrochloride	nAChR	Neurological Disease
Adiphenine hydrochloride is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC₅₀s of 1.9, 1.8, 3.7, and 6.3 µM for α1, α3β4, α4β2, and α4β4, respectively. Adiphenine hydrochloride has anticonvulsant effects .

HY-Y1314

Dimethyl sulfone 1 Publications Verification
Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective .

HY-B0405A

Bupivacaine hydrochloride 3 Publications Verification	iGluR Sodium Channel Calcium Channel Potassium Channel	Neurological Disease Cancer
Bupivacaine hydrochloride is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC₅₀ of 69.5 μM. Bupivacaine hydrochloride can be used for the research of chronic pain .

HY-B0364A

Dyclonine hydrochloride 1 Publications Verification Dyclocaine hydrochloride	Bacterial Fungal Aldehyde Dehydrogenase (ALDH)	Infection Cancer
Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC₅₀ of 35 µM for ALDH2 and 76 µM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local anesthetic that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain .

HY-B0985A

Phenazopyridine 2 Publications Verification
Phenazopyridine is a competitive SARM1 inhibitor, with IC₅₀ 145 μM. Phenazopyridine is a TRPM8 antagonist. Phenazopyridine has a local anesthetic/analgesic effect. Phenazopyridine is used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine can promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases .

HY-B0405S

Bupivacaine-d9	Isotope-Labeled Compounds iGluR Sodium Channel Calcium Channel Potassium Channel	Neurological Disease
Bupivacaine-d₉9 is a deuterium labeled Bupivacaine. Bupivacaine is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain[1][2][3].

HY-B0985

Phenazopyridine hydrochloride 2 Publications Verification	TRP Channel	Neurological Disease
Phenazopyridine hydrochlorideis a competitive SARM1 inhibitor, with IC₅₀ 145 μM. Phenazopyridine hydrochlorideis a TRPM8 antagonist. Phenazopyridine hydrochloride has a local anesthetic/analgesic effect. Phenazopyridine hydrochlorideis used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine hydrochloridecan promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases .

HY-B0517A

Mepivacaine hydrochloride	Sodium Channel	Neurological Disease
Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization .

HY-B0986

Hexylresorcinol 4-Hexylresorcinol	Parasite Bacterial Apoptosis Glucosidase Endogenous Metabolite	Infection Metabolic Disease Cancer
Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of α-glucosidase. Hexylresorcinol has protective effects against oxidative DNA damage .

Alkaloids Library	528 compounds
Alkaloids are a large and complex group of cyclic compounds that contain N. About 2,000 different alkaloids have been isolated. Important alkaloids include morphine, strychnine, atropine, colchicine, ephedrine, quinine, and nicotine. Alkaloids are useful as diet ingredients, supplements, and pharmaceuticals, in medicine and in other applications in human life. They showed anti-inflammatory, anticancer, analgesics, local anesthetic and pain relief, neuropharmacologic, antimicrobial, antifungal, and many other activities. Alkaloids are also important compounds in organic synthesis for searching new semisynthetic and synthetic compounds with possibly better biological activity than parent compounds. MCE designs a unique collection of 528 alkaloids that all come from natural products. MCE Alkaloids Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

Glycinexylidide GX	Biochemical Assay Reagents
Glycinexylidide (GX) is the active metabolite of Lidocaine. Lidocaine is a local anesthetic that inhibits sodium channels involving complex voltage and dependence. Lidocaine also reduces the growth, migration and invasion of gastric cancer cells. Glycinexylidide has research potential for use in anesthesia, cancer, and cardiovascular disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0986

Hexylresorcinol 4-Hexylresorcinol	Infection Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Parasite Bacterial Apoptosis Glucosidase Endogenous Metabolite
Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of α-glucosidase. Hexylresorcinol has protective effects against oxidative DNA damage .

Cat. No.	Product Name	Chemical Structure

HY-B0517S

Mepivacaine-d3
Mepivacaine-d₃ is the deuterium labeled Mepivacaine. Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization[1][2].

HY-B0405S

Bupivacaine-d9
Bupivacaine-d₉9 is a deuterium labeled Bupivacaine. Bupivacaine is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain[1][2][3].

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

local anesthetic

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Natural
Products